Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Always Active
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.

Meet Pseudomonas aeruginosa

What is it?

Drug-resistant Pseudomonas aeruginosa is associated with 559,000 deaths every year, placing it among the most lethal bacterial pathogens globally. Although P. aeruginosa infections are rare in healthy people, they pose a serious risk to vulnerable and critically ill patients, including those with weakened immune systems, severe lung conditions, or traumatic burns. P. aeruginosa is highly versatile, being able to infect different parts of the body including the lungs, skin and bloodstream.

 

How is it spread?

P. aeruginosa can use a wide range of sources to obtain nutrients for growth, and can survive in different levels of oxygen, meaning it can live almost anywhere. It can grow in liquid and as a layer of cells on a surface, called a biofilm, helping it to thrive in both natural and artificial settings. It is commonly found in water, soil, fruit and vegetables.

Infections are usually acquired by touching contaminated fluids and objects. The abundance of P. aeruginosa makes prevention of infection challenging. P. aeruginosa can be a particular issue in some hospital settings especially those with vulnerable patients, as it can contaminate medical equipment such as catheters and ventilation devices.

Gardp Sm Landscape Superbug Pa

Where is it found?

Drug-resistant P. aeruginosa infections are a global threat. Having spread around the world, P. aeruginosa is estimated to cause around 7% of all healthcare-associated infections, and nearly a quarter of all infections are acquired in intensive care units. It is a leading cause of death in patients with cystic fibrosis. Patients with chronic obstructive pulmonary disease also suffer recurrent exacerbations of Pseudomonas infections.

Several outbreaks of P. aeruginosa have been attributed to contaminated water systems in hospitals, with sinks, drains and toilets in healthcare settings becoming contaminated and infecting patients. This can occur through direct contact, sprays, splashes or through inhalation.

 

Drug resistance

Like other Gram-negative bacteria, P. aeruginosa is naturally resistant to antibiotics because of its protective outer layer, which blocks drugs from entering the bacterial cell. Even if antibiotics do manage to penetrate this outer layer, P. aeruginosa can pump them back out again using numerous efflux pumps.

Moreover, P. aeruginosa has acquired many different drug resistance mechanisms. This can occur through the mutation of genes, such as those encoding proteins targeted by antibiotics, making it harder for drugs to bind to them, or ones that increase the production of efflux pumps, which can decrease the entry of antibiotics into the cell. It can also acquire resistant genes from other bacteria. One way P. aeruginosa does this is by acquiring genes which produce enzymes that inactivate and/or destroy many different classes of antibiotics. Of special concern is the marked rise of P. aeruginosa strains resistant to carbapenems, a class of last-resort antibiotics, because in this case safe and efficacious treatment options are very limited.