Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings
Antimicrobial resistance (AMR) is a major and growing threat to global health, development, and security, with the greatest burden borne by low-income and middle-income countries (LMICs). Without urgent intervention, cumulative deaths between 2020 and 2050, attributable to AMR, are projected to be 39·1 million globally. Effective diagnostics are important to bacterial pathogen detection and antimicrobial susceptibility testing, and such diagnostics support antibiotic stewardship by reducing adverse drug events (eg, toxicity or allergy) and restricting the emergence and spread of AMR. Yet, access to appropriate diagnostics in LMICs remains constrained.
Authors
Valeria Gigante PhD, Maurine Murtagh JD, Prof Till T Bachmann PhD, Tamarie Rocke MD, Betsy W Trainor BSc, Susan M Poutanen MD MPH, Teri Roberts PhD, Prof Jordi Vila MD PhD, Alexandra Cameron PhD