Serious bacterial infections

Serious bacterial infections are a major cause of death in hospitals and healthcare settings. Bacteria can enter the body through wounds and surgery sites, ventilators and catheters, leading to pneumonia, urinary tract, abdominal and bloodstream infections. The Global Antibiotic Research and Development Partnership (GARDP) is working to develop new treatments for these serious bacterial infections, focusing on treatments for drug-resistant bacteria on the World Health Organization’s (WHO) priority pathogens list.

In Europe, hospital infections cause 37,000 deaths and contribute to an additional 110,000 deaths every year; in the US they are responsible for 98,000 deaths every year. In low- and middle-income countries, where less data is available, indicators paint a grim picture. Infections associated with ventilators and catheters in developing countries are up to 19 times higher than in the United States. The rate of hospital infections among newborns in low-income countries is up to 20 times higher than in high-income countries.

Drug resistance makes these infections more difficult to treat. In turn, surgical procedures and chemotherapy carry greater risk. Between 39% and 51% of bacteria causing surgical site infections, and 27% causing infections after chemotherapy, are now resistant to commonly used antibiotics.

Addressing serious bacterial infections

The most difficult to treat infections in hospitals are caused by Enterobacterales, Pseudomonas aeruginosa and Acinetobacter bacteria. Known as Gram-negative bacteria, they have built-in abilities to find new ways to resist treatment and can pass along genetic material that allows other bacteria to become drug resistant as well.

These bacteria have become resistant to many commonly used antibiotics, including carbapenems, a class of antibiotics reserved for multidrug-resistant infections. They are identified by the WHO as ‘critical level’ priority pathogens urgently requiring new treatments and among the greatest threats to health. GARDP is working with partners to develop urgently needed treatments for these priority bacteria, but more global action is required to tackle this urgent threat.

A new treatment for multidrug-resistant infections

GARDP is partnering with Venatorx Pharmaceuticals on a novel antibiotic called cefepime-taniborbactam. Taniborbactam is a beta-lactamase inhibitor, meaning it neutralizes enzymes that can allow bacteria to develop resistance to certain types of antibiotics. Taniborbactam, used in combination with the antibiotic cefepime, restores the ability of this drug to work against serious bacterial infections, including those caused by multidrug-resistant Enterobacterales and Pseudomonas aeruginosa.

Under its collaboration agreement, GARDP is responsible for trials activities to evaluate cefepime-taniborbactam as a treatment for adults with multidrug-resistant infections, as well as trials to evaluate the treatment for children, including babies with serious bacterial infections.

GARDP and Venatorx are committed to working together to distribute cefepime-taniborbactam on an affordable basis worldwide. GARDP has exclusive rights to distribute and sub-distribute cefepime-taniborbactam in most low- and lower middle-income countries. Download an overview of the collaboration agreement between GARDP and Venatorx. Download collaboration overview >

“Hospitals should be places people go to heal, but around the world many patients acquire life-threatening infections in hospitals. WHO is delighted that GARDP is entering into this new partnership to drive the development of urgently needed new antibiotics for such drug-resistant hospital-acquired infections.”

– Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization

The burden of serious bacterial infections is significantly higher in developing countries, compared with high-income countries, in particular in people admitted to adult and neonatal intensive care units. Unavailable drugs and insufficient supplies also put lives at risk. GARDP is working to ensure newly developed treatments are available to every person who needs them, wherever they live.

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Many medicines are only designed for adults. Half of medicines prescribed for children have not been developed specifically for them or have not been proven to be safe and effective for their use. GARDP is working with partners to ensure newly developed treatments for serious bacterial infections are evaluated for use in children. Read more about GARDP’s programme in the publication In Focus: Serious Bacterial Infections.

Download In Focus: Serious Bacterial Infections >

 

Prioritizing pathogens and saving lives

The WHO ‘priority pathogens list’ is a catalogue of drug-resistant bacteria that pose the greatest threat to health. The list was drawn up to guide research and development of new antibiotics. There are three tiers within the list: critical, high and medium. The most critical group includes multidrug-resistant bacteria that pose a particular threat in hospitals and healthcare settings, and among people whose care requires devices such as ventilators and catheters. GARDP’s work to develop treatments for serious bacterial infections focuses on these critical-level pathogens.

Sustainable Development Goals

GARDP’s mission to develop treatments for drug-resistant infections, for every person who needs them, is aligned with Sustainable Development Goal 3: Ensure healthy lives and promote well-being for all at all ages. Targets within this goal, known as SDG3, include ending preventable deaths of newborns and children, supporting the research and development of medicines for diseases that disproportionately impact developing countries, and ensuring access to effective and affordable essential medicines.

Partnering to prevent a global health emergency

The economic cost of hospital infections

Serious bacterial infections lead to longer hospital stays, long-term disability and more preventable deaths. This hurts economic growth, costing the European economy €7 billion and US economy $6.5 billion annually. In low- and middle-income countries, indicators suggest the financial impact is more severe. Developing new treatments to fight serious bacterial infections frees up more money to invest in healthcare and fuels economic development.

GARDP is working to develop five treatments for drug-resistant infections by 2025. By partnering with GARDP you support lifesaving work to develop new treatments, for every person who needs them.

Learn more about partnering with GARDP >

Learn about GARDP’s discovery and exploratory research programme.

Discovery & exploratory research
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