Research & Development
The research and development work of the Global Antibiotic Research and Development Partnership (GARPD) is focused on urgently needed treatments for bacteria on the World Health Organization priority pathogens list, as well as for people disproportionately affected by drug resistance, including babies, children and hospitalized adults. GARDP is addressing critically underfunded and unfilled gaps in the development of treatments by tracking, evaluating and contributing where others are not.
Research and development focus
- Clinical development: supporting development from phase 2 trials through to regulatory approval and post-approval evidence.
- Enabling science: non-clinical science activities to support the evaluation and regulatory approval of treatments.
- Formulation and manufacturing: improving drug formulations to ensure affordability, adaptability and effective distribution.
- Regulatory pathways: defining pathways from initial approval to country-level submission through consultation with regulatory authorities and WHO.
- Public health evidence: generating post-approval evidence for policy, guidelines and appropriate clinical use.
- Sustainable access: developing appropriate-use guidance to support the sustainability of new antibiotics.
Discovery and exploratory research
GARDP is working to identify novel antibiotics from new and under-exploited antimicrobial substances that show promising activity against bacteria, in order to develop them into treatments for drug-resistant infections. GARDP is also working on educational and knowledge-sharing activities in antibiotic research and development.
Every year 3 million babies and 1.2 million children suffer from sepsis, a life-threatening complication of infection. Three out of every ten neonatal sepsis deaths result from drug-resistant bacteria. GARDP is developing new treatments as well as evidence to the support the use of existing antibiotics for babies and children.
Infection rates of gonorrhoea are increasing, with 87 million new cases each year. This infection can lead to infertility and ectopic pregnancy and increases the risk of HIV transmission. Gonorrhoea has progressively developed resistance to available treatments. GARDP is developing a new gonorrhoea treatment.
Serious bacterial infections in hospitalized adults
Serious bacterial infections are among the major cause of death for people in hospitals. The impact of drug resistance is often worst in hospitals, because they are high-risk environments for the spread of infections. GARDP is working on treatments for Gram-negative bacteria, which are the most resistant forms of infections.
“Preventing the very real scenario of a world without effective antibiotics will require particularly enhanced research and development activities. GARDP is ideally placed to build the required partnerships to deliver new treatments for priority public health needs.”
– Anja Karliczek, Federal Research Minister, German Federal Research Ministry of Education and Research